LLOYD FRICKER

ALBERT EINSTEIN COLLEGE OF MEDICINE – USA
Professor in the Departments of Molecular Pharmacology and Neuroscience at Albert Einstein College of Medicine. He is a pioneer in the field of peptidomics and also in the field of neuropeptide processing. In the 1980s, Dr. Fricker discovered the enzyme which is the final step in the biosynthesis of most neuropeptides and peptide hormones and in the 1990s found that a naturally occurring mutation (named the fat mutation) was due to a defect in this enzyme and abnormal processing of neuropeptides. This led to development of a method to affinity purify neuropeptide precursors from mutant mouse brain and the use of mass spectrometry to identify the peptides. Several novel neuropeptides were discovered using this peptidomics methods, including some of the most abundant neuropeptides in mouse brain. Subsequently, Dr. Fricker contributed to the development of quantitative peptidomics methods using isotopic labels and LC-MS. He is the author of over 200 scien tific papers and book chapters, and has written a book on peptides and two advice/humor books for scientists.